Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair.

ABSTRACT: Peripheral nerve injuries result in disrupted cellular communication between the central nervous system and somatic distal end targets. The peripheral nervous system is capable of independent and extensive regeneration; however, meaningful target muscle reinnervation and functional recovery remain limited and may result in chronic neuropathic pain and diminished quality of life. Macrophages, the primary innate immune cells of the body, are critical contributors to regeneration of the injured peripheral nervous system. However, in some clinical scenarios, macrophages may fail to provide adequate support with optimal timing, duration, and location. Here, we review the history of immunosuppressive and immunomodulatory strategies to treat nerve injuries. Thereafter, we enumerate the ways in wh

SUBMITTER: Wofford KL 

PROVIDER: S-EPMC8712351 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature