Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011.

ABSTRACT:

Objectives

To assess associations between maternal smoking and congenital heart defects (CHDs) in offspring.

Study design

We performed a retrospective case-control study using data for cases of CHD (n = 8339) and nonmalformed controls (n = 11 020) from all years (1997-2011) of the National Birth Defects Prevention Study. Maternal self-reported smoking 1 month before through 3 months after conception was evaluated as a binary (none, any) and categorical (light, medium, heavy) exposure. Multivariable logistic regression was used to estimate aOR and 95% CIs. Stratified analyses were performed for septal defects according to maternal age, prepregnancy body mass index, and maternal race/ethnicity.

Results

Multiple CHDs displayed modest associations with any level of matern

SUBMITTER: Bolin EH 

PROVIDER: S-EPMC8712361 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature