Oral Ondansetron Administration in Children Seeking Emergency Department Care for Acute Gastroenteritis: A Patient-Level Propensity-Matched Analysis.

ABSTRACT:

Study objective

This study aimed to explore oral ondansetron usage and impact on outcomes in clinical practice.

Methods

This observational study was a planned secondary analysis of 2 trials conducted in 10 US and 6 Canadian institutions between 2014 and 2017. Children 3 to 48 months old with gastroenteritis and ≥3 episodes of vomiting in the 24 hours preceding emergency department (ED) presentation were included. Oral ondansetron was administered at the discretion of the provider. The principal outcomes were intravenous fluid administration and hospitalization at the index visit and during the subsequent 72 hours and diarrhea and vomiting frequency during the 24 hours following the ED visit.

Results

In total, 794 children were included. The median age was 16.0 months

SUBMITTER: Powell EC 

PROVIDER: S-EPMC8712362 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature