Podoplanin promotes tumor growth, platelet aggregation, and venous thrombosis in murine models of ovarian cancer.

ABSTRACT:

Background

Podoplanin (PDPN) is a sialylated membrane glycoprotein that binds to C-type lectin-like receptor 2 on platelets resulting in platelet activation. PDPN is expressed on lymphatic endothelial cells, perivascular fibroblasts/pericytes, cancer cells, cancer-associated fibroblasts, and tumor stromal cells. PDPN's expression on malignant epithelial cells plays a role in metastasis. Furthermore, the expression of PDPN in brain tumors (high-grade gliomas) was found to correlate with an increased risk of venous thrombosis.

Objective

We examined the expression of PDPN and its role in tumor progression and venous thrombosis in ovarian cancer.

Methods

We used mouse models of ovarian cancer and venous thrombosis.

Results

Ovarian cancer cells express PDPN and rele

SUBMITTER: Sasano T 

PROVIDER: S-EPMC8712373 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature