Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system x_c.

ABSTRACT: System x_c ^- (Sx_c ^- ) is a heteromeric antiporter (L-cystine/L-glutamate exchanger) expressed predominately on astrocytes in the central nervous system. Its activity contributes importantly to the maintenance of the ambient extracellular glutamate levels, as well as, to cellular redox homeostasis. Since alterations in glutamate levels and redox modifications could cause structural changes, we analyzed gross regional morphology of thionin-stained brain sections and cellular and subcellular morphology of Golgi-Cox stained layer V pyramidal neurons in the primary motor cortex (PM1) of mice naturally null for SLC7A11 (SLC7A11^sut/sut )-the gene that encodes the substrate specific light chain (xCT) for Sx_c ^- . Intriguing

SUBMITTER: Sears SMS 

PROVIDER: S-EPMC8712388 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature