Genetic and environmental influences on the progression from alcohol use disorder to alcohol-related medical conditions.

ABSTRACT:

Background

Medical conditions related to alcohol use disorders (AUD) represent a substantial public health concern. However, only a subset of individuals with AUD develop these conditions and the extent to which genetic and environmental factors that are shared with AUD, versus those distinct from it, contribute to this progression has not yet been determined.

Methods

Using data from Swedish national registries for a cohort born from 1932 to 1970 (N = 1,319,214, 48.9% women), we conducted twin-sibling biometric model fitting to examine the genetic and environmental sources of variance that contribute to the liability to alcohol-related medical conditions (AMC). Progression to AMC, determined using medical registry data, was contingent on an AUD registration, which was determ

SUBMITTER: Edwards AC 

PROVIDER: S-EPMC8712390 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature