Surface phenotypes of naive and memory B cells in mouse and human tissues.

ABSTRACT: Memory B cells (MBCs) protect the body from recurring infections. MBCs differ from their naive counterparts (NBCs) in many ways, but functional and surface marker differences are poorly characterized. In addition, although mice are the prevalent model for human immunology, information is limited concerning the nature of homology in B cell compartments. To address this, we undertook an unbiased, large-scale screening of both human and mouse MBCs for their differential expression of surface markers. By correlating the expression of such markers with extensive panels of known markers in high-dimensional flow cytometry, we comprehensively identified numerous surface proteins that are differentially expressed between MBCs and NBCs. The combination of these markers allows for the identification

SUBMITTER: Weisel NM 

PROVIDER: S-EPMC8712407 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature