Cariprazine in the Treatment of Bipolar Disorder: Within and Beyond Clinical Trials.

ABSTRACT: Bipolar disorder (BD) is chronic psychiatric disorder associated with significant impairment in psychosocial functioning and quality of life. Although current pharmacological treatments for BD have improved its clinical management, many patients do not achieve remission, particularly those suffering from bipolar depression. In addition, available treatments are associated with a myriad of potential adverse effects, which highlights the need for novel therapeutic agents that can be effective for both phases of the illness with a reduced side effect burden. Cariprazine is a novel antipsychotic that is a dopamine D2/D3 partial agonist with a preference for D3 receptors. In this review, we examine the pharmacological properties, clinical efficacy and tolerability profile of cariprazine in pati

SUBMITTER: Do A 

PROVIDER: S-EPMC8712443 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature