Interruption of the tricarboxylic acid cycle in Staphylococcus aureus leads to increased tolerance to innate immunity.

ABSTRACT: Staphylococcus aureus is widely known for its resistance and virulence causing public health concerns. However, antibiotic tolerance is also a contributor to chronic and relapsing infections. Previously, it has been demonstrated that persister formation is dependent on reduced tricarboxylic acid (TCA) cycle activity. Persisters have been extensively examined in terms of antibiotic tolerance but tolerance to antimicrobial peptides (AMPs) remains largely unexplored. AMPs are a key component of both the human and Drosophila innate immune response. TCA cycle mutants were tested to determine both antibiotic and AMP tolerance. Challenging with multiple classes of antibiotics led to increased persister formation (100- to 1,000-fold). Similarly, TCA mutants exhibited AMP tolerance wi

SUBMITTER: Hobbs AM 

PROVIDER: S-EPMC8712538 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature