Protein Function Prediction Based on PPI Networks: Network Reconstruction vs Edge Enrichment.

ABSTRACT: Over the past decades, massive amounts of protein-protein interaction (PPI) data have been accumulated due to the advancement of high-throughput technologies, and but data quality issues (noise or incompleteness) of PPI have been still affecting protein function prediction accuracy based on PPI networks. Although two main strategies of network reconstruction and edge enrichment have been reported on the effectiveness of boosting the prediction performance in numerous literature studies, there still lack comparative studies of the performance differences between network reconstruction and edge enrichment. Inspired by the question, this study first uses three protein similarity metrics (local, global and sequence) for network reconstruction and edge enrichment in

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8712557 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature