Atypical perineuronal nets in the CA2 region interfere with social memory in a mouse model of social dysfunction.

ABSTRACT: Social memory dysfunction is an especially devastating symptom of many neuropsychiatric disorders, which makes understanding the cellular and molecular processes that contribute to such abnormalities important. Evidence suggests that the hippocampus, particularly the CA2 region, plays an important role in social memory. We sought to identify potential mechanisms of social memory dysfunction in the hippocampus by investigating features of neurons, glia, and the extracellular matrix (ECM) of BTBR mice, an inbred mouse strain with deficient social memory. The CA2 is known to receive inputs from dentate gyrus adult-born granule cells (abGCs), neurons known to participate in social memory, so we examined this cell population and found fewer abGCs, as well as fewer axons from abGCs in the CA2 of

SUBMITTER: Cope EC 

PROVIDER: S-EPMC8712624 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature