Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention.

ABSTRACT: Vitiligo is a chronic autoimmune depigmenting skin disorder characterized by patches of the skin losing functional melanocytes. Multiple combinatorial factors are involved in disease development, among which immune T cells play a prominent role. The immune cells implicated in melanocyte destruction through adaptive immunity include CD8⁺ cytotoxic T cells and regulatory T cells, and aberrantly activated skin-resident memory T cells also play a role in melanocyte destruction. Over the past several years, major progress in understanding vitiligo pathogenesis has led to the development of targeted therapies. Janus kinase (JAK) inhibitors, which share the similar mechanism that autoactivates CD8⁺ T cells in chronic inflammatory diseases, have been reported to have therapeu

SUBMITTER: Chang WL 

PROVIDER: S-EPMC8712646 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature