Human myocardial mitochondrial oxidative capacity is impaired in mild acute heart transplant rejection.

ABSTRACT:

Aims

Acute cellular rejection (ACR) following heart transplantation (HTX) is associated with long-term graft loss and increased mortality. Disturbed mitochondrial bioenergetics have been identified as pathophysiological drivers in heart failure, but their role in ACR remains unclear. We aimed to prove functional disturbances of myocardial bioenergetics in human heart transplant recipients with mild ACR by assessing myocardial mitochondrial respiration using high-resolution respirometry, digital image analysis of myocardial inflammatory cell infiltration, and clinical assessment of HTX patients. We hypothesized that (i) mild ACR is associated with impaired myocardial mitochondrial respiration and (ii) myocardial inflammation, systemic oxidative stress, and myocardial oedema relate t

SUBMITTER: Scheiber D 

PROVIDER: S-EPMC8712779 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature