Impact of renin-angiotensin system inhibitors on long-term clinical outcomes of patients with rheumatic heart disease.

ABSTRACT:

Aims

Rheumatic heart disease (RHD) remains a major global health problem. Renin-angiotensin-aldosterone system inhibitors (RAASi) are commonly administered in the treatment of cardiovascular disease, but its role in RHD patients is still limited. We performed a retrospective study to determine the effect of RAASi on long-term outcomes for RHD patients.

Methods and results

A 1:1 propensity score matching was implemented to balance baseline characteristics between groups RAASi and non-RAASi. Cox proportional hazards regression model was used to investigate the associations of RAASi with the risks of all-cause mortality, cardiovascular death (CVD), and cerebrovascular death. Binary logistic regression analysis was used to evaluate the associations of RAASi with the risks of 1,

SUBMITTER: Liu C 

PROVIDER: S-EPMC8712808 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature