Role of skeletal muscle perfusion and insulin resistance in the effect of dietary sodium on heart function in overweight.

ABSTRACT:

Aims

Weight excess and insulin resistance predispose to heart failure. High sodium consumption may contribute to the development of cardiac impairment in insulin-resistant individuals by promoting inadequate skeletal muscle microvascular perfusion response to insulin. We sought to investigate the association of dietary sodium reduction with muscle perfusion, insulin sensitivity, and cardiac function in overweight/obese insulin-resistant (O-IR) normotensive subjects.

Methods and results

Fifty O-IR individuals with higher than recommended sodium intake were randomized to usual or reduced sodium diet for 8 weeks; 25 lean, healthy subjects served as controls for pre-intervention measurements. Echocardiography and muscle perfusion were performed during fasting and under stable eu

SUBMITTER: Keske MA 

PROVIDER: S-EPMC8712816 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature