Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart.

ABSTRACT:

Aims

Recent evidence has demonstrated that ketone bodies, particularly β-hydroxybutyrate (BHB), are beneficial to the failing heart due to their potential as an alternative energy substrate as well as their anti-inflammatory and anti-oxidative properties. Exogenous supplementation of ketones also helps prevent heart failure (HF) development in rodent models, but whether ketones can be used to treat HF remains unexplored. Herein, we investigated whether chronic supplementation of ketones is beneficial for the heart in a mouse model of established HF.

Methods and results

To elevate circulating ketone levels, we utilized (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate [ketone ester (KE)]. C57Bl/6N male mice were subjected to transverse aortic constriction (TAC) surgery. After developi

SUBMITTER: Takahara S 

PROVIDER: S-EPMC8712827 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature