Risk factors and prediction models for incident heart failure with reduced and preserved ejection fraction.

ABSTRACT:

Aims

This study aims to develop the first race-specific and sex-specific risk prediction models for heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF).

Methods and results

We created a cohort of 1.8 million individuals who had an outpatient clinic visit between 2002 and 2007 within the Veterans Affairs (VA) Healthcare System and obtained information on HFpEF, HFrEF, and several risk factors from electronic health records (EHR). Variables were selected for the risk prediction models in a 'derivation cohort' that consisted of individuals with baseline date in 2002, 2003, or 2004 using a forward stepwise selection based on a change in C-index threshold. Discrimination and calibration were assessed in the remaining participants (internal 'validation cohor

SUBMITTER: Gaziano L 

PROVIDER: S-EPMC8712836 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature