Levosimendan-induced venodilation is mediated by opening of potassium channels.

ABSTRACT: Unique vascular responses adhere to the cardiovascular efficacy of the inodilator levosimendan. In particular, selective venodilation appears to explain its clinical benefit during pulmonary hypertension complicated by heart failure with preserved ejection fraction. Vasodilators increase vessel diameter in various parts of the vascular system to different degrees and thereby influence blood pressure, its distribution, and organ perfusion depending on their mechanisms of action. Levosimendan and its long-lived active metabolite OR-1896 mobilize a set of vasodilatory mechanisms, that is, the opening of the ATP-sensitive K⁺ channels and other K⁺ channels on top of a highly selective inhibition of the phosphodiesterase III enzyme. A vessel-specific combination of the abov

SUBMITTER: Burkhoff D 

PROVIDER: S-EPMC8712848 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature