Risk factors for left ventricular dysfunction in adulthood: role of low birth weight.

ABSTRACT:

Aims

This study aimed to determine the relationship of low birth weight (LBW) with adult cardiac structure and function and investigate potential causal pathways.

Methods and results

A population-based sample of 925 Australians (41.3% male) were followed from childhood (aged 7-15 years) to young adulthood (aged 26-36 years) and mid-adulthood (aged 36-50 years). Left ventricular (LV) global longitudinal strain (GLS, %), LV mass index (LVMi, g/m^2.7 ), LV filling pressure (E/e'), and left atrial volume index (g/m² ) were measured by transthoracic echocardiography in mid-adulthood. Birth weight category was self-reported in young adulthood and classified as low (≤5 lb or ≤2270 g), normal (5-8 lb or 2271-3630 g), and high (>8 lb or >3630 g). Of the 925 parti

SUBMITTER: Huynh QL 

PROVIDER: S-EPMC8712853 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature