Plasma amino acid profiling improves predictive accuracy of adverse events in patients with heart failure.

ABSTRACT:

Aims

The clinical outcome of heart failure (HF) is complicated by the presence of multiple comorbidities including malnutrition and cachexia, and prediction of the outcome is still difficult in each patient. Metabolomics including amino acid profiling enables detection of alterations in whole body metabolism. The aim of this study was to determine whether plasma amino acid profiling improves prediction of clinical outcomes in patients with HF.

Methods and results

We retrospectively examined 301 HF patients (70 ± 15 years old; 59% male). Blood samples for measurements of amino acid concentrations were collected in a fasting state after stabilization of HF. Plasma amino acid concentrations were measured using ultraperformance liquid chromatography. Clinical endpoint of this st

SUBMITTER: Kouzu H 

PROVIDER: S-EPMC8712896 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature