Early Transcriptional Changes in Rabies Virus-Infected Neurons and Their Impact on Neuronal Functions.

ABSTRACT: Rabies is a zoonotic disease caused by rabies virus (RABV). As rabies advances, patients develop a variety of severe neurological symptoms that inevitably lead to coma and death. Unlike other neurotropic viruses that can induce symptoms of a similar range, RABV-infected post-mortem brains do not show significant signs of inflammation nor the structural damages on neurons. This suggests that the observed neurological symptoms possibly originate from dysfunctions of neurons. However, many aspects of neuronal dysfunctions in the context of RABV infection are only partially understood, and therefore require further investigation. In this study, we used differentiated neurons to characterize the RABV-induced transcriptomic changes at the early time-points of infection. We found that the

SUBMITTER: Kim S 

PROVIDER: S-EPMC8713068 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature