Multimodal MRI cerebral correlates of verbal fluency switching and its impairment in women with depression.

ABSTRACT:

Background

The search of biomarkers in the field of depression requires easy implementable tests that are biologically rooted. Qualitative analysis of verbal fluency tests (VFT) are good candidates, but its cerebral correlates are unknown.

Methods

We collected qualitative semantic and phonemic VFT scores along with grey and white matter anatomical MRI of depressed (n = 26) and healthy controls (HC, n = 25) women. Qualitative VFT variables are the "clustering score" (i.e. the ability to produce words within subcategories) and the "switching score" (i.e. the ability to switch between clusters). The clustering and switching scores were automatically calculated using a data-driven approach. Brain measures were cortical thickness (CT) and fractional anisotropy (FA). We tested for

SUBMITTER: Domain L 

PROVIDER: S-EPMC8713114 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature