Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?

ABSTRACT: Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associated with a high prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment and depression. Along with traditional cardiovascular risk factors (such as diabetes, inflammation, hypertension and dyslipidaemia), non-traditional risk factors related to kidney damage (such as uraemic toxins) may predispose patients with CKD to neurological disorders. There is increasing evidence to show that ur

SUBMITTER: Liabeuf S 

PROVIDER: S-EPMC8713157 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature