Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti.

ABSTRACT: Natural product discovery by isolation and structure elucidation is a laborious task often requiring ample quantities of biological starting material and frequently resulting in the rediscovery of previously known compounds. However, peptides are a compound class amenable to an alternative genomic, transcriptomic, and in silico discovery route by similarity searches of known peptide sequences against sequencing data. Based on the sequences of barrettides A and B, we identified five new barrettide sequences (barrettides C-G) predicted from the North Atlantic deep-sea demosponge Geodia barretti (Geodiidae). We synthesized, folded, and investigated one of the newly described barrettides, barrettide C (NVVPCFCVEDETSGAKTCIPDNCDASRGTNP, disulfide connectivity I-IV, II-III). Co-elut

SUBMITTER: Steffen K 

PROVIDER: S-EPMC8713285 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature