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Current status of non-surgical treatment of locally advanced pancreatic cancer.


ABSTRACT: Pancreatic cancer is the 7th leading cause of death due to cancer in industrialized countries and the 11th most common cancer globally, with 458918 new cases (2.5% of all cancers) and 432242 deaths (4.5% of all cancer deaths) in 2018. Unfortunately, 80% to 90% of the patients present with unresectable disease, and the reported 5-year survival rate range between 10% and 25%, even after successful resection with tumor-free margins. Systemic chemotherapy, radiotherapy, and minimally invasive image-guided procedures that have emerged over the past years, are used for the management of non-operable PC. This review focuses on currently available non-surgical options of locally advanced pancreatic cancer.

SUBMITTER: Spiliopoulos S 

PROVIDER: S-EPMC8713317 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Current status of non-surgical treatment of locally advanced pancreatic cancer.

Spiliopoulos Stavros S   Zurlo Maria Teresa MT   Casella Annachiara A   Laera Letizia L   Surico Giammarco G   Surgo Alessia A   Fiorentino Alba A   de'Angelis Nicola N   Calbi Roberto R   Memeo Riccardo R   Inchingolo Riccardo R  

World journal of gastrointestinal oncology 20211201 12


Pancreatic cancer is the 7<sup>th</sup> leading cause of death due to cancer in industrialized countries and the 11<sup>th</sup> most common cancer globally, with 458918 new cases (2.5% of all cancers) and 432242 deaths (4.5% of all cancer deaths) in 2018. Unfortunately, 80% to 90% of the patients present with unresectable disease, and the reported 5-year survival rate range between 10% and 25%, even after successful resection with tumor-free margins. Systemic chemotherapy, radiotherapy, and min  ...[more]

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