Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions.

ABSTRACT: Schizophrenia (SCZ) is a psychiatric disorder that can include symptoms of disorganized speech and thoughts with uncertain underlying mechanisms possibly linked to over-activated microglia. In this study, we used brain samples from sixteen donors with SCZ and thirteen control donors to assess the differential activation of microglia by quantifying density and 3D reconstruction of microglia stained with ionized calcium-binding adaptor molecule-1 (Iba1). Our samples consisted of sections from the frontal, temporal, and cingulate cortical gray matter, subcortical white matter regions (SCWM), and included the anterior corpus callosum. In the first series of studies, we performed a density analysis followed by a spatial analysis to ascertain the microglial density, distribution, and soma size i

SUBMITTER: Gober R 

PROVIDER: S-EPMC8713533 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature