Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index.

ABSTRACT:

Background

The exposome is defined as encompassing all environmental exposures one undergoes from conception onwards. Challenges of the application of this concept to environmental-health association studies include a possibly high false-positive rate.

Objectives

We aimed to reduce the dimension of the exposome using information from DNA methylation as a way to more efficiently characterize the relation between exposome and child body mass index (BMI).

Methods

Among 1,173 mother-child pairs from HELIX cohort, 216 exposures ("whole exposome") were characterized. BMI and DNA methylation from immune cells of peripheral blood were assessed in children at age 6-10 years. A priori reduction of the methylome to preselect BMI-relevant CpGs was performed using biological pathw

SUBMITTER: Cadiou S 

PROVIDER: S-EPMC8713647 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature