Cell-type-specific neuromodulation guides synaptic credit assignment in a spiking neural network.

ABSTRACT: Brains learn tasks via experience-driven differential adjustment of their myriad individual synaptic connections, but the mechanisms that target appropriate adjustment to particular connections remain deeply enigmatic. While Hebbian synaptic plasticity, synaptic eligibility traces, and top-down feedback signals surely contribute to solving this synaptic credit-assignment problem, alone, they appear to be insufficient. Inspired by new genetic perspectives on neuronal signaling architectures, here, we present a normative theory for synaptic learning, where we predict that neurons communicate their contribution to the learning outcome to nearby neurons via cell-type-specific local neuromodulation. Computational tests suggest that neuron-type diversity and neuron-type-specific local neuromodul

SUBMITTER: Liu YH 

PROVIDER: S-EPMC8713766 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature