Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons.

ABSTRACT: Fast oscillations in cortical circuits critically depend on GABAergic interneurons. Which interneuron types and populations can drive different cortical rhythms, however, remains unresolved and may depend on brain state. Here, we measured the sensitivity of different GABAergic interneurons in prefrontal cortex under conditions mimicking distinct brain states. While fast-spiking neurons always exhibited a wide bandwidth of around 400 Hz, the response properties of spike-frequency adapting interneurons switched with the background input's statistics. Slowly fluctuating background activity, as typical for sleep or quiet wakefulness, dramatically boosted the neurons' sensitivity to gamma and ripple frequencies. We developed a time-resolved dynamic gain analysis and revealed rapid sensitivity m

SUBMITTER: Merino RM 

PROVIDER: S-EPMC8713793 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature