Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors.

ABSTRACT: G protein-coupled receptors (GPCRs) are the largest family of human proteins. They have a common structure and, signaling through a much smaller set of G proteins, arrestins, and effectors, activate downstream pathways that often modulate hallmark mechanisms of cancer. Because there are many more GPCRs than effectors, mutations in different receptors could perturb signaling similarly so as to favor a tumor. We hypothesized that somatic mutations in tumor samples may not be enriched within a single gene but rather that cognate mutations with similar effects on GPCR function are distributed across many receptors. To test this possibility, we systematically aggregated somatic cancer mutations across class A GPCRs and found a nonrandom distribution of positions with variant amino acid residues

SUBMITTER: Huh E 

PROVIDER: S-EPMC8713800 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature