Prediction errors disrupt hippocampal representations and update episodic memories.

ABSTRACT: The brain supports adaptive behavior by generating predictions, learning from errors, and updating memories to incorporate new information. Prediction error, or surprise, triggers learning when reality contradicts expectations. Prior studies have shown that the hippocampus signals prediction errors, but the hypothesized link to memory updating has not been demonstrated. In a human functional MRI study, we elicited mnemonic prediction errors by interrupting familiar narrative videos immediately before the expected endings. We found that prediction errors reversed the relationship between univariate hippocampal activation and memory: greater hippocampal activation predicted memory preservation after expected endings, but memory updating after surprising endings. In contrast to previous studi

SUBMITTER: Sinclair AH 

PROVIDER: S-EPMC8713973 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature