Genomic, Immunological, and Clinical Characterization of Pyroptosis in Ovarian Cancer.

ABSTRACT:

Purpose

Pyroptosis is a form of lytic programmed cell death that is associated with the pathogenesis of many tumors. However, the potential roles of pyroptosis-related genes (PRGs) in the tumor microenvironment (TME) remain unclear.

Materials and methods

We systematically described the genetic and transcriptional alterations in PRGs in gynecological cancers. An unsupervised clustering method was used to investigate the molecular subtypes of ovarian cancer (OV) and systematically analyze the TME cell infiltration characteristics. A prognostic signature and nomogram were established to quantify the pyroptosis patterns of individual tumors. We also analyzed the expression levels of eight PRGs in the OV tissues.

Results

Two distinct molecular subtypes of OV were identifie

SUBMITTER: Zhou M 

PROVIDER: S-EPMC8714015 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature