Development of hepatocellular carcinoma from various phases of chronic hepatitis B virus infection.

ABSTRACT:

Background & aims

There is insufficient data on the clinical course of chronic hepatitis B (CHB) patients in the immune-tolerant (IT) and immune-clearance, inactive (IC) phases over a long follow-up period.

Design

We enrolled 466 CHB patients from our historical cohort, including 56 IT+MA　 (mildly active), 134 IC, 230 with chronic active hepatitis (CH) and 46 with liver cirrhosis (LC), who were categorized to each phase by at least one year of follow-up period from the first visit to our hospital. We investigated long-term risks, and their factors, of developing hepatocellular carcinoma (HCC), and the transition between the clinical phases, especially in the IT+MA and IC groups.

Results

Of the 56 patients in the IT+MA group, 27 remained the IT+MA phase, but 29 transit

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC8714106 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature