Moraxella-dominated pediatric nasopharyngeal microbiota associate with upper respiratory infection and sinusitis.

ABSTRACT:

Background

Distinct bacterial upper airway microbiota structures have been described in pediatric populations, and relate to risk of respiratory viral infection and, exacerbations of asthma. We hypothesized that distinct nasopharyngeal (NP) microbiota structures exist in pediatric populations, relate to environmental exposures and modify risk of acute sinusitis or upper respiratory infection (URI) in children.

Methods

Bacterial 16S rRNA profiles from nasopharyngeal swabs (n = 354) collected longitudinally over a one-year period from 58 children, aged four to seven years, were analyzed and correlated with environmental variables, URI, and sinusitis outcomes.

Results

Variance in nasopharyngeal microbiota composition significantly related to clinical outcomes, participan

SUBMITTER: McCauley KE 

PROVIDER: S-EPMC8714118 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature