Identification of a novel immune signature for optimizing prognosis and treatment prediction in colorectal cancer.

ABSTRACT:

Background

Globally, colorectal cancer (CRC) is one of the most lethal malignant diseases. However, the currently approved therapeutic options for CRC failed to acquire satisfactory treatment efficacy. Tailoring therapeutic strategies for CRC individuals can provide new insights into personalized prediction approaches and thus maximize clinical benefits.

Methods

In this study, a multi-step process was used to construct an immune-related genes (IRGs) based signature leveraging the expression profiles and clinical characteristics of CRC from the Gene Expression Omnibus (GEO) database and the Cancer Genome Atlas (TCGA) database. An integrated immunogenomic analysis was performed to determine the association between IRGs with prognostic significance and cancer genotypes in the t

SUBMITTER: Li Y 

PROVIDER: S-EPMC8714135 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature