A novel immune-related long non-coding RNAs risk model for prognosis assessment of lung adenocarcinoma.

ABSTRACT:

Background

The abundant immune-related long non-coding RNA (IRLNRs) in immune cells and immune microenvironment have the potential to forecast prognosis and evaluate the effect of immunotherapy. IRLNRs analysis will provide a new perspective for LUAC research.

Methods

We calculated the immune score of each sample according to the expression levels of immune-related genes (IRGs) and screened the survival-related IRLNRs (sIRLNRs) by Cox regression analysis. The expression levels of AC068338.3 and AL691432.2 in tissues and cell lines were confirmed by RT-qPCR.

Results

36 IRLNRs were selected by Pearson correlation analysis. Ten sIRLNRs were significantly correlated with the clinical outcomes of LUAC patients. Five sIRLNRs were identified by multivariate COX regression an

SUBMITTER: Lu S 

PROVIDER: S-EPMC8714149 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature