Functional rare variant in a C/EBP beta binding site in NINJ2 gene increases the risk of coronary artery disease.

ABSTRACT:

Objective

NINJ2 regulates activation of vascular endothelial cells, and genome-wide association studies showed that variants in NINJ2 confer risk to stroke. However, whether variants in NINJ2 are associated with coronary artery disease (CAD) is unknown.

Methods

We genotyped rs34166160 in NINJ2 in two independent Chinese GeneID populations which included 2,794 CAD cases and 4,131 controls, and performed genetics association studies. Functional studies were also performed to reveal the mechanisms.

Results

Allele rs34166160 significantly confers risk to CAD in the GeneID Hubei population which contained 1,440 CAD cases and 2,660 CAD-free controls (observed P_-obs = 6.39 × 10^-3 with an odds ratio (OR) was 3.39, adjus

SUBMITTER: Wang P 

PROVIDER: S-EPMC8714150 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature