Landscape of the oncogenic role of fatty acid synthase in human tumors.

ABSTRACT:

Background

Identifying a unique and common regulatory pathway that drives tumorigenesis in cancers is crucial to foster the development of effective treatments. However, a systematic analysis of fatty acid synthase across pan-cancers has not been carried out.

Methods

We investigated the oncogenic roles of fatty acid synthase in 33 cancers based on the cancer genome atlas and gene expression omnibus.

Results

Fatty acid synthase is profoundly expressed in most cancers and is an important factor in predicting the outcome of cancer patients. Further, the level of S207 phosphorylation was found to be improved in several neoplasms (e.g., colon cancer). Fatty acid synthase expression is related to tumor-infiltrating immune cells in tumors (e.g., CD8+ T-cell infiltration leve

SUBMITTER: Huo X 

PROVIDER: S-EPMC8714155 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature