Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging.

ABSTRACT: Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated diseases and mortality. However, the association between epigenetic age acceleration and hearing remains unknown. Our study aims to investigate the relationship between epigenetic age acceleration and audiometric hearing in the Baltimore Longitudinal Study of Aging (BLSA). Methods: Participants with both DNA methylation and audiometric hearing measurements were included. The main independent variables are epigenetic age acceleration measures, including intrinsic epigenetic age acceleration-"IEAA," Hannum age acceleration-"AgeAccelerationRe

SUBMITTER: Kuo PL 

PROVIDER: S-EPMC8714776 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature