The effects of violet and blue light irradiation on ESKAPE pathogens and human cells in presence of cell culture media.

ABSTRACT: Bacteria belonging to the group of ESKAPE pathogens are responsible for the majority of nosocomial infections. Due to the increase of antibiotic resistance, alternative treatment strategies are of high clinical relevance. In this context visible light as disinfection technique represents an interesting option as microbial pathogens can be inactivated without adjuvants. However cytotoxic effects of visible light on host cells have also been reported. We compared the cytotoxicity of violet and blue light irradiation on monocytic THP-1 and alveolar epithelium A549 cells with the inactivation effect on ESKAPE pathogens. THP-1 cells displayed a higher susceptibility to irradiation than A549 cells with first cytotoxic effects occurring at 300 J cm^-2 (405 nm) and 400 J cm^-2

SUBMITTER: Bauer R 

PROVIDER: S-EPMC8714816 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature