Evaluation of [⁶⁸Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis.

ABSTRACT: The ⁶⁸Gallium-labeled 1,4,7-triazacyclononane-1-glutaric acid-4,7-diacetic acid conjugated radiolabelled arginine-glycine-aspartic acid peptide ([⁶⁸Ga]Ga-NODAGA-RGD) is a positron emission tomography (PET) tracer binding to cell surface receptor α_vβ₃ integrin that is upregulated during angiogenesis and inflammation. We studied whether α_vβ₃ targeting PET imaging can detect myocardial inflammation in a rat model of autoimmune myocarditis. To induce myocarditis, rats (n = 8) were immunized with porcine cardiac myosin in complete Freund's adjuvant on days 0 and 7. Control rats (n = 8) received Freund's adjuvant alone. On day 21, in vivo PET/CT imaging with [⁶⁸Ga]Ga-NODAGA-RGD followed by ex viv

SUBMITTER: Jahandideh A 

PROVIDER: S-EPMC8714834 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature