Novel Insights Into Gene Signatures and Their Correlation With Immune Infiltration of Peripheral Blood Mononuclear Cells in Behcet's Disease.

ABSTRACT:

Background

Behcet's disease (BD) is a chronic inflammatory disease that involves systemic vasculitis and mainly manifests as oral and genital ulcers, uveitis, and skin damage as the first clinical symptoms, leading to gastrointestinal, aortic, or even neural deterioration. There is an urgent need for effective gene signatures for BD's early diagnosis and elucidation of its underlying etiology.

Methods

We identified 82 differentially expressed genes (DEGs) in BD cases compared with healthy controls (HC) after combining two Gene Expression Omnibus datasets. We performed pathway analyses on these DEGs and constructed a gene co-expression network and its correlation with clinical traits. Hub genes were identified using a protein-protein interaction network. We manually selected

SUBMITTER: Zhan H 

PROVIDER: S-EPMC8714896 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature