Comparison of the Effects of Oral Midazolam and Intranasal Dexmedetomidine on Preoperative Sedation and Anesthesia Induction in Children Undergoing Surgeries.

ABSTRACT: Background and Purpose: Premedication with either oral midazolam or intranasal dexmedetomidine prior to surgery remains less than ideal. The aim of this study was to investigate whether the combination of those two drug regimens would have any beneficial effects on the preoperative sedation and the children's compliance during anesthesia inhalation induction. Experimental Approach: One hundred thirty-eight children aged 2-6 years were randomly allocated into three groups: Group M with oral midazolam 0.5 mg kg^-1, Group D with intranasal dexmedetomidine 2 μg kg^-1, and Group M + D with intranasal dexmedetomidine 1 μg kg^-1 plus oral midazolam 0.5 mg kg^-1. The primary outcome was the children's compliance during inhalation induction with

SUBMITTER: Cai YH 

PROVIDER: S-EPMC8714926 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature