Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1.

ABSTRACT: The major transmembrane protein of the red blood cell, known as band 3, AE1, and SLC4A1, has two main functions: 1) catalysis of Cl^-/[Formula: see text] exchange, one of the steps in CO₂ excretion, and 2) anchoring the membrane skeleton. This review summarizes the 150-year history of research on red cell anion transport and band 3 as an experimental system for studying membrane protein structure and ion transport mechanisms. Important early findings were that red cell Cl^- transport is a tightly coupled 1:1 exchange and band 3 is labeled by stilbenesulfonate derivatives that inhibit anion transport. Biochemical studies showed that the protein is dimeric or tetrameric (paired dimers) and that there is one stilbenedisulfonate binding site per sub

SUBMITTER: Jennings ML 

PROVIDER: S-EPMC8714990 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature