Diverse role of decoys on emergence and precision of oscillations in a biomolecular clock.

ABSTRACT: Biomolecular clocks are key drivers of oscillatory dynamics in diverse biological processes including cell-cycle regulation, circadian rhythms, and pattern formation during development. A minimal clock implementation is based on the classical Goodwin oscillator, in which a repressor protein inhibits its own synthesis via time-delayed negative feedback. Clock motifs, however, do not exist in isolation; its components are open to interacting with the complex environment inside cells. For example, there are ubiquitous high-affinity binding sites along the genome, known as decoys, where transcription factors such as repressor proteins can potentially interact. This binding affects the availability of transcription factors and has often been ignored in theoretical studies. How does such genomic

SUBMITTER: Dey S 

PROVIDER: S-EPMC8715246 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature