Effect of Vitamin D Supplementation on Outcomes in People With Early Psychosis: The DFEND Randomized Clinical Trial.

ABSTRACT:

Importance

People with psychotic disorders have an increased risk of vitamin D deficiency, which is evident during first-episode psychosis (FEP) and associated with unfavorable mental and physical health outcomes.

Objective

To examine whether vitamin D supplementation contributes to improved clinical outcomes in FEP.

Design, setting, and participants

This multisite, double-blind, placebo-controlled, parallel-group randomized clinical trial from the UK examined adults 18 to 65 years of age within 3 years of a first presentation with a functional psychotic disorder who had no contraindication to vitamin D supplementation. A total of 2136 patients were assessed for eligibility, 835 were approached, 686 declined participation or were excluded, 149 were randomized, and 104

SUBMITTER: Gaughran F 

PROVIDER: S-EPMC8715346 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature