Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.

ABSTRACT:

Rationale

Methamphetamine (MA) addiction is a major public health issue in the USA, with a poorly understood genetic component. We previously identified heterogeneous nuclear ribonucleoprotein H1 (Hnrnph1; H1) as a quantitative trait gene underlying sensitivity to MA-induced behavioral sensitivity. Mice heterozygous for a frameshift deletion in the first coding exon of H1 (H1^+/-) showed reduced MA phenotypes including oral self-administration, locomotor activity, dopamine release, and dose-dependent differences in MA conditioned place preference. However, the effects of H1^+/- on innate and MA-modulated reward sensitivity are not known.

Objectives

We examined innate reward sensitivity and facilitation by MA in H1^+/- mice via intracranial self-

SUBMITTER: Borrelli KN 

PROVIDER: S-EPMC8715365 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature