Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP^C, in type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Normal cellular prion protein (PrP^C) is a conserved mammalian glycoprotein found on the outer plasma membrane leaflet through a glycophosphatidylinositol anchor. Although PrP^C is expressed by a wide range of tissues throughout the body, the complete repertoire of its functions has not been fully determined. The misfolded pathogenic isoform PrP^Sc (the scrapie form of PrP) is a causative agent of neurodegenerative prion diseases. The aim of this study is to evaluate PrP^C localisation, expression and trafficking in pancreases from organ donors with and without type 1 diabetes and to infer PrP^C function through studies on interacting protein partners.

Methods

In order to evaluate localisation and trafficking

SUBMITTER: Hiller H 

PROVIDER: S-EPMC8715394 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature