The rise and the fall of a Pseudomonas aeruginosa endemic lineage in a hospital.

ABSTRACT: The biological features that allow a pathogen to survive in the hospital environment are mostly unknown. The extinction of bacterial epidemics in hospitals is mostly attributed to changes in medical practice, including infection control, but the role of bacterial adaptation has never been documented. We analysed a collection of Pseudomonas aeruginosa isolates belonging to the Besançon Epidemic Strain (BES), responsible for a 12year nosocomial outbreak, using a genotype-to-phenotype approach. Bayesian analysis estimated the emergence of the clone in the hospital 5 years before its opening, during the creation of its water distribution network made of copper. BES survived better than the reference strains PAO1 and PA14 in a copper solution due to a genomic island containing 13 metal-r

SUBMITTER: Petitjean M 

PROVIDER: S-EPMC8715434 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature