Revisiting the heterogeneous global genomic population structure of Leishmania infantum.

ABSTRACT: Leishmania infantum is the main causative agent responsible for visceral leishmaniasis (VL), a disease with global distribution. The genomic structure and genetic variation of this species have been widely studied in different parts of the world. However, in some countries, this information is still yet unknown, as is the genomic behaviour of the main antigens used in VL diagnosis (rK39 and rK28), which have demonstrated variable sensitivity and specificity in a manner dependent on the geographic region analysed. The objective of this study was to explore the genomic architecture and diversity of four Colombian L. infantum isolates obtained in this study and to compare these results with the genetic analysis of 183 L. infantum isolates from across the world (obt

SUBMITTER: Patino LH 

PROVIDER: S-EPMC8715437 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature